Introduction

        Non-coding RNAs in Inflammation (ncRI) provides a manually curated database for experimentally validated non-coding RNAs in inflammation. Inflammation is a series of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. Recently, inflammation is considered to be central to the onset, progression, and outcome of infectious and noninfectious diseases, especially believed as a hallmark of cancer. In addition, the inflammatory agents, such as cytokines and chemokines, can regulate the behavior of the immune system and involve in the immunotherapy. For example, IL-2 can enhance anti-tumor activity and is used in the treatment of malignant melanoma and renal cell carcinoma. With the discovery of non-coding RNAs (miRNA, lncRNA and so on), a further level of complexity in the control of immunity and inflammation processes at a molecular level arouses interest in research. NcRNAs play important roles in the inflammation processes and represent new potential targets for immunotherapy. For example, miR-9 significantly repressed NF-kB expression, and thereby promoted lymphatic endothelial cell (LEC) tube formation in lymphatic inflammatory processes. The expression of miR-146a was significantly increased in rheumatoid arthritis (RA), positively correlated with expression level of TNF-alpha in CD4+ T cells, and critically involved in modulating T cell apoptosis. MiR-155 was induced during the macrophage inflammatory response, and pharmacological inhibition of the kinase JNK blocked induction of miR-155 in response to TNF-alpha, suggesting that miR-155 could be an effective target for anti-inflammation .
        However, the knowledge about inflammation related ncRNAs scattered in a large amount of literatures without a systematic recording. In this study, we presented a database ncRI which collected experimentally validated non-coding RNAs in inflammation from published articles. The related publications were manually curated from the PubMed database. Then, entries about ncRNAs and their roles in inflammation were retrieved. We obtained detailed information about ncRNA name, the description of the ncRNA involved processes, inflammatory diseases, mechanism, experimental techniques (e.g., microarray, RNA-seq, qRT-PCR), experimental samples (cell line and/or tissue), expression patterns of ncRNA (up-regulated or down-regulated), reference information (PubMed ID, year of publication, title of paper) and so on. We believe that ncRI provides a relatively comprehensive repository about the experimentally validated ncRNAs and their roles in inflammation, and will be helpful for research on immunotherapy.

Search

Users can input the interested ncRNA and/or disease of selected species to retrieve the data. ncRI supports the fuzzy search, and when a ncRNA (disease) is selected, the related disease (ncRNA) is listed in the corresponding drop-down box.

The search result of the inputted items

The detailed information of the selceted the items

Browse

Users can browse the interested micRNA, lncRNA,other ncRNA and disease in selceted species

The result page of the selected ncRNA or disease in the Browse page. The detailed information were the same as described in Search

Download

All the data in the ncRI are freely to be downloaded

Submit

Users can submit the new data to ncRI. The red star represents the required items