Introduction Statistics
  As two kinds of important gene expression regulators, both epigenetic modification and miRNA can play significant roles in a wide range of complex diseases. Recently, many studies have demonstrated that epigenetics and miRNA can regulate each other in many biological processes. For instance, methylation of promoter-associated CpG dinucleotides (especially in CpG islands) usually correlates with reduced transcription levels of corresponding miRNAs and subsequently induces the expression of miRNA target genes. Additionally, histone modifications have been discovered to play positive or negative roles in controlling miRNA expression in various normal cells and diseases. On the other hand, miRNA exerts its curative effects on regulating DNA methylation or histone modification through directly targeting epigenetic enzymes or functional protein complexes. Thus, we developed a comprehensive database named EpimiR to store the experimentally validated mutual regulations between epigenetic modifications and miRNAs. The EpimiR database have obtained 1974 regulatory relationships between 19 types of epigenetic modifications (including DNA methylation, histone acetylation, H3K4me3 and H3K27me3, etc.) and 617 miRNAs across 7 species (including Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Epstein Barr virus, Canis familiaris and Arabidopsis thaliana) from nearly 2000 literatures. The records that were stored in the EpimiR database can be divided into 2 parts: Epi2miR and miR2Epi. Users can search, submit, and download with a user-friendly interface.
Creation Date: Jun. 10, 2013

Number of species: 7
Number of MiRNAs: 617
Number of Epigenetics: 19
Number of Epi2miR entries: 1871
Number of miR2Epi entries: 103

Citation: Dai E, Yu X, Zhang Y, Meng F, Wang S, Liu X, Liu D, Wang J, Li X, Jiang W. EpimiR: a database of curated mutual regulation between miRNAs and epigenetic modifications. Database. 2014 Mar 28; 2014(0):bau023. doi: 10.1093/database/bau023.
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